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A study from the University of Arizona discovered that an enzyme with a key role in severe inflammation may be a vital mechanism in COVID-19 severity and could provide a new target for medicine development.The researchers collaborated with Stony Brook University and Wake Forest School of Medicine to analyze blood samples from two COVID-19 patients and discovered that the circulation of the sPLA2-11A enzyme may be an important method in predicting which patients would die of COVID-19.At high levels, the enzyme has the ability to “shred” the membranes of vital organs.“It’s a bell-shaped curve of disease resistance versus host tolerance,” said Floyd (ski) Chilton, senior author on the paper and director of the UArizona Precision Nutrition and Wellness Initiative at the university. “In other words, this enzyme is trying to kill the virus, but at a certain point it is released in such high amounts that things head in a really bad direction, destroying the patient’s cell membranes and thereby contributing to multiple organ failure and death.”
www.jpost.com/science/does-this-enzyme-raise-the-chance-of-covid-related-death-678710
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