California is under some of the strictest controls in the nation, Arizona has a statewide curfew among other restrictions, and Rhode Island has extended its lockdown orders until January 28.

Arizona currently has the highest per-capita rate of new Covid-19 infections, with 785 cases per 100,000 people over the past seven days. That rate not only leads the U.S., but is the highest in the world, according to NBC News data. For comparison, the Czech Republic, the country with the highest per-capita rate of infection, has reported 653 cases per 100,000 over the past seven days.

Rhode Island and California also have higher per-capita rates of infection than any other country. Over the past seven days, Rhode Island reported 671 new cases per 100,000, and California had 658 per 100,000.

The U.S. reported an average of 451 new cases per 100,000 a day over the past seven days. That is the 10th highest countrywide rate in the world, though several of the nations that are ahead of the U.S. — including San Marino and Lichtenstein — are much smaller.

The staggeringly high rates of infection foretell the challenges that lie ahead, and experts are still expecting to see increases associated with the holidays, despite the Centers for Disease Control and Prevention urging people to avoid gatherings and limit travel.

The trends are especially worrisome for states that are already under siege. Hospitals in California have been overwhelmed as the state grapples with record numbers of daily deaths and hospitalizations.

In Los Angeles County, which saw its case numbers increase by 905 percent since Nov. 1, 10 people are getting sick with Covid-19 every minute, L.A. Mayor Eric Garcetti said Sunday in an interview with CBS News’ “Face the Nation.”