Complexity Of The Nanoparticle Story

by SP

 

An engineer friend sent me this summary article this morning on the use of custom made nano-particles for vaccines.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4977448/

Vaccine adjuvants are applied to amplify the recipient’s specific immune responses against pathogen infection or malignancy. A new generation of adjuvants is being developed to meet the demands for more potent antigenspecific responses, specific types of immune responses, and a high margin of safety. Nanotechnology provides a multifunctional stage for the integration of desired adjuvant activities performed by the building blocks of tailor-designed nanoparticles. Using nanomaterials for antigen delivery can provide high bioavailability, sustained and controlled release profiles, and targeting and imaging properties resulting from manipulation of the nanomaterials’ physicochemical properties. Moreover, the inherent immune-regulating activity of particular nanomaterials can further promote and shape the cellular and humoral immune responses toward desired types.

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The hypothesis (vaccine aluminum->transport to brain–>inflammation–>autism) emphasizes the distribution and transport of aluminum (Al) to the brain via macrophages and the positive feed back loop created when macrophage chemotactic protein-1 (MCP-1) is released in inflammed brain tissue drawing even more Al ladened macrophages through the Blood Brain Barrier and into the brain tissue.  And all  of this is done without significant rise in the soluble Al concentrations.

The macrophage functions as a trojan horse getting the al particles through the BBB into brain tissue.

Minimizing Al containing vaccines while this is worked out seems smart to me.

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