This Simple Test May Help Diagnose Cytokine Storm Early On, Remember The Name If You Get sick

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I urge everyone to make a print out of possible tests and drugs that may help if you should become sick and or end up at the hospital

Add it to your list of daily meds so that you can discuss your treatment options

CHEAP SIMPLE TEST 

Ask for a SERUM FERRITIN test

Symptoms include high fever, enlarged spleen, excessive bleeding, low counts of all types of blood cells (red, white and platelets) and, potentially, multiple organ failures.

A cheap, simple test, widely available at most hospitals in the United States and worldwide, can help diagnose cytokine storm syndrome, Cron said.

“A protein called serum ferritin tends to get very high in this disorder,” he said.

“If you are sick enough to be in a hospital and you have a fever, you should get a serum ferritin.

It typically comes back in less than 24 hours and almost every hospital can do it, and if it’s high you can work them up for cytokine storm syndrome.”

www.uab.edu/reporter/know-more/publications/item/8909-here-s-a-playbook-for-stopping-deadly-cytokine-storm-syndrome

Keep this in mind….although the numbers are not up to date the R0 seems to be rising

It took eight months for SARS to spread to more than 8,000 people.

The Wuhan coronavirus infected over 20,000 people in about five weeks.

One month into SARS outbreak, only five people had died.

The new coronavirus had killed at least 213 people by the one-month mark.

www.businessinsider.com/china-wuhan-coronavirus-compared-to-sars-2020-1

In the past week, at least six teams of researchers, along with the World Health Organization, have published estimates of R0 for the new coronavirus.

All these groups used different methods, but their results have been mostly consistent, with estimates hovering between 2 and 3.

WHO was a little more conservative than the others, with estimates of 1.4 to 2.5.

One Chinese team is a clear outlier, with estimates of 3.3 to 5.5.

And a British-led group initially published a high average value of 3.8 last week before revising it downward to 2.5 as new data emerged.

www.theatlantic.com/science/archive/2020/01/how-fast-and-far-will-new-coronavirus-spread/605632/

Cytokine and chemokine measurement

To characterise the effect of coronavirus on the production of cytokines or chemokines in the acute phase of the illness, plasma cytokines and chemokines (IL1B, IL1RA, IL2, IL4, IL5, IL6, IL7, IL8 (also known as CXCL8), IL9, IL10, IL12p70, IL13, IL15, IL17A, Eotaxin (also known as CCL11), basic FGF2, GCSF (CSF3), GMCSF (CSF2), IFNγ, IP10 (CXCL10), MCP1 (CCL2), MIP1A (CCL3), MIP1B (CCL4), PDGFB, RANTES (CCL5), TNFα, and VEGFA were measured using Human Cytokine Standard 27-Plex Assays panel and the Bio-Plex 200 system (Bio-Rad, Hercules, CA, USA) for all patients according to the manufacturer’s instructions. 

www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

‘Patients WHO DEVELOPED ONLY MODERATE SYMPTOMS @ THE ONSET OF WUHAN VIRUS LATER FELL SERIOUSLY ILL & DIED OF MULTIPLE ORGAN FAILURE

focustaiwan.tw/sci-tech/202002090008

The good news is that “we now have a variety of therapeutic options to treat cytokine storm syndrome,” Cron said.

“But especially a lot of the older physicians don’t know what this is.”

That was one of Cron’s primary motivating factors in writing his book, he said. “Cytokine Storm Syndrome” offers detailed descriptions of symptoms and clinical presentations, along with the latest treatments and care regimens.

“The sooner you recognize it, the better the outcomes,” Cron said.

“If we can get people to diagnose this in the ER and the ICU, that would be ideal.”

www.uab.edu/reporter/know-more/publications/item/8909-here-s-a-playbook-for-stopping-deadly-cytokine-storm-syndrome

Based on the promising results mentioned above, combination therapies pairing S1PR and PPAR agonists, COX-2 inhibitors, and antioxidants with conventional antiviral agents are promising treatments that deserve further study in randomized clinical trials.

Other approaches, especially those therapeutic strategies that can target signaling pathways, either to suppress redundant immune responses or reduce viral replication, will be particularly noteworthy.

Therapies in link……

www.ncbi.nlm.nih.gov/pmc/articles/PMC4711683/

 

 

h/t kpm

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