Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19)
In light of this, a countermeasure that has been shown to be effective in high altitude illness is Acetazolamide.
Acetazolamide has a myriad of effects on different organ systems . It potently reduces hypoxic pulmonary vasoconstriction . Improved minute ventilation and expired vital capacity has been shown in climbers taking Acetazolamide as well .
Other therapeutics that have been shown to be effective in the analogous condition of HAPE and that are directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors (Table (Table2)2) [25,26].
|Ground Glass Opacities on Chest CT||Present||Present|
|Patchy Infiltrates on Chest X-RAY||Present||Present|
|Fibrinogen levels/Fibrin formation||Increased||Increased|
|Acute Respiratory Distress Syndrome Development in Severe Disease||Present||Present|
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